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'Microneedle' Patches Claim a Pain-Free Vaccination Experience

microneedle patch
A new vaccine delivery system is being developed by Georgia Tech and Emory University: a small patch embedded with 100 "microneedles" that is, supposedly, almost painless. The needles themselves are about 0.65 milimeters long, filled with frozen vaccine and applied to the skin like a Band-Aid. Once the needles have deposited their weakened virus, they dissolve into the skin and leave no trace. Since the length of the needles fall somewhere between the thinnest and thickest parts of the epidermis (about 0.10 millimeters in the eyelids and 1.5 millimeters in the soles of the feet) and because they dissolve so quickly, the researchers claim a practically pain-free experience.

Alternatives to syringe-injected vaccines, of course, aren't new. In 1960, Aaron Ismach patented the Jet Injector, which uses high pressure to shoot a narrow stream of the vaccine fluid straight into the skin, for use in mass smallpox vaccinations -- although the process was not exactly painless. The new microneedle patch would benefit from the same advantages as the Jet Injector -- less training would be required to administer and more people could be vaccinated in a given time -- but it also shows promise as the most efficient delivery system.

The researchers tested the patch with flu vaccine on mice alongside another group inoculated via syringe; three months later, after being exposed to influenza, the patch mice showed an improved immunological response over the syringe group. According to the researchers, the skin is the optimal place for delivering a vaccine (as opposed to intramuscularly) since it contains an abundance of cells that trigger the immune response to the vaccine.

Don't expect, though, to pick up a patch in the drugstore any time soon. Besides the fact that the patches have not yet entered into human clinical trials, we have to imagine that they'll be treated as any other prescription and require a doctor's scrawl. Still, it's great news for those afraid of needles (who isn't?), and especially for anyone whose parents bought in to Andrew Wakefield's insanity about vaccination causing autism. In reality, vaccines cause your child not to die. [From: WebMD]


Tags: biotech, EmoryUniversity, georgia tech, GeorgiaTech, health, jet injector, JetInjector, medical, medicine, microneedles, needles, science, top, vaccinations, vaccine

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